HIV Vaccine Development.
نویسنده
چکیده
Several interesting new vaccine-related studies were presented at the 16th Conference on Retroviruses and Opportunistic Infections this year. Transmitted viruses appear to be derived from cell-free virus rather than cell-associated virus, at least in men who have sex with men. Follow-up studies from the Step (HIV Vaccine Trials Network 502) trial indicated that if individuals mounted certain vaccine-induced responses, they may control viral replication after infection. Finally, adeno-associated-virus-derived neutralizing antibodies completely protected macaques from infection, suggesting novel mechanisms of viral control.
منابع مشابه
A Shot at Dendritic Cell-Based Vaccine Strategy against HIV-1
Introduction: Despite considerable efforts to control AIDS pandemic, it is still one of the significant infectious concerns worldwide. The advance in medical research has led to the development of highly active antiretroviral therapy with a considerable effect to suppress the disease. However, an effective vaccine capable of eradication the HIV pandemic is not available yet. Failure to develop ...
متن کاملImmune Responses against a New HIV-1 p24-gp41/pCAGGS-IL-12 DNA Vaccine in Balb/c Mice
Background: Development of an effective vaccine is highly needed in order to restrict the AIDS pandemic. DNA vaccines initiate both arms of immunity without the potential of causing disease. HIV-1 p24 and gp41 (gag and env) proteins play important roles in viral pathogenesis and are effective candidates for immune induction and vaccine design. Objective: In this study, new DNA vaccine candidate...
متن کاملGlobal Efforts against HIV Epidemic and HIV Vaccine Development
Although the tremendous effort has been paid by scientists for creating HIV vaccine over the past three decades since the discovery of HIV-1, the HIV vaccine development still has a long way to go. Only one HIV vaccine, RV144, has been proved to be moderately effective by the clinical trials, but there has been much debate about its usefulness. The difficulties of HIV vaccine development includ...
متن کاملHIV vaccine development: challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem.
Recent advances in HIV vaccine development have created a renaissance in the search for a safe and effective HIV vaccine. These advances include the first demonstration in human clinical trials of a vaccine candidate that provided modest levels of protection from HIV infection; a series of candidates entering into clinical trials with an improved profile of protection against SIV in non-human p...
متن کاملStrategies for an HIV vaccine
The development of an HIV vaccine poses an unprecedented challenge to the scientific community. The inexorable spread of HIV worldwide and the devastating clinical consequences of AIDS can only be contained by an effective vaccine. Yet, almost two decades after the first demonstration of HIV and its etiologic role in AIDS, this vaccine still is a goal, not a reality. In this Perspective, I cons...
متن کاملA review of vaccine research and development: the human immunodeficiency virus (HIV).
Since the discovery of AIDS in 1981, the global spread of HIV has reached pandemic proportions, representing a global developmental and public health threat. The development of a safe, globally effective and affordable HIV vaccine offers the best hope for the future control of the pandemic. Significant progress has been made over the past years in the areas of basic virology, immunology, pathog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Topics in HIV medicine : a publication of the International AIDS Society, USA
دوره 18 2 شماره
صفحات -
تاریخ انتشار 2009